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Skin ageing is inevitable, yet in the realm of skincare, there is a vast range of treatments available to replenish hydration and rejuvenate the skin. That includes the latest trending treatment: polynucleotides. This innovative treatment has swept the aesthetics market, offering a minimally invasive solution to achieving vibrant, healthy looking and feeling skin. In this post, we’ll explore what a polynucleotide is and how it’s specially crafted formulation can bring a wide array of advantages.

How do polynucleotides work?

Polynucleotides are an injectable treatment used to stimulate repair and rejuvenation deep under the surface of the skin. They are similar to products such as skin boosters, but rather than just providing hydration, polynucleotides kickstart processes that provide food or medicine for our cells, speeding up repair and turnover to create healthy skin.

The science behind polynucleotides

Polynucleotides are often formulated using the DNA of sperm from fish such as salmon and trout. The sperm is used as it resembles human DNA very closely. When injected, they stimulate fibroblasts within our body which are a type of cell that play a role in the formation of connective tissues. They also contribute to the production of collagen proteins. This process stimulates the tissues and cells to repair themselves, and propels cell turnover. Collagen production also increases because of this, kickstarting the production of elastin too.

Polynucleotides are created using the DNA from salmon, picture of salmon on a table close up

What is the difference between polynucleotides and PDRN?

You may seen the term PDRN appear when searching polynucleotides and it can be confusing deciphering what the differences or similarities are between them both. Polydeoxyribonucleotides (PDRN) are a type of polynucleotides (PN). Both PDRN and polynucleotides provide the same properties like healing and rejuvenation however polynucleotides are a more concentrated and purified form.

What can polynucleotides be used for?

With the confusion of what polynucleotides are, also comes the confusion of what they can be used for. Here are some of the many problems polynucleotides can target:

Acne scarring

The stimulation of collagen and tissue repair can improve any skin texture that can appear post-acne and improve the appearance of scarring on the surface of the skin.


Polynucleotides can aid in creating a thicker, stronger skin barrier reducing the symptoms that come alongside conditions such as rosacea.

Deep lines and wrinkles

By increasing the production of collagen and elastin, polynucleotides reduce the appearance of any fine lines or deep wrinkles in areas such as the sides of the mouth and even around the eyes.


Polynucleotides can reduce melanin production which is the pigment in our bodies responsible for producing dark spots and hyperpigmentation. It can aid in fading these skin concerns and prevent new ones from appearing.

Rehydration & rejuvenation

The molecules that form polynucleotides are great at attracting water molecules that can improve dry, dehydrated skin conditions. Collagen also aids in rehydration but also plays a role in rejuvenating the skin to reduce dullness.

Polynucleotides reduce the appearance of wrinkles and fine lines, close up shot of a woman with wrinkles on the side of her eyes
Polynucleotides can reduce the appearance of rosacea of the skin, close up shot of a woman's lower half of face

How long do they take to work?

Polynucleotides require around 3 sessions of treatment to be fully effective but most patients report seeing a difference after 3-5 weeks. Having multiple sessions allows active stimulation of fibroblast production too which can maximise the results and increase longevity.

What side effects are there?

Patients may experience some minimal side effects after treatment including redness, swelling and bruising like most injectable procedures. These should subside within a week.

How long do results last?

Polynucleotides can last up to 12-18 months but this is ultimately dependant on also maintaining a healthy diet, exercising regularly and reducing alcohol consumption also. These factors play a role in creating healthy tissue.

What polynucleotide should I use?

Here at Refine Pharma, we recommend our best selling polynucleotide Nucleofill.


Nucleofill is a polynucleotide used to rejuvenate the skin. It has a high viscosity formulation that aids in producing long lasting results. There are three products in the Nucleofill range, including Nucelofill Strong, Nucelofill Medium and Nucelofill Soft Plus. They vary in what effects they create on the skin, from subtly lifting and plumping the skin to reducing wrinkles and fine lines.

Buy Nucleofill Here
Nucelofill Strong product box on a light blue background